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digestive Langerhans cell histiocytosis
Tuesday 8 February 2011
Gastrointestinal (GI) tract involvement by Langerhans cell histiocytosis (LCH) is a rare condition. It is typically noted in male patients with systemic disease and is associated with both poor prognosis and high morbidity. The incidence peaks in childhood. However, a limited number of cases have been reported in adults.
GI tract LCH lesions present in both children and adults with a female predominance.
Consistent with earlier reports, pediatric cases are associated with systemic disease and poor prognosis.
In adults, LCH is typically encountered as an incidental, solitary polyp. Rare cases of systemic disease may occur and, therefore, close follow-up may be warranted.
References
Gastrointestinal Tract Langerhans Cell Histiocytosis: AClinicopathologic Study of 12 Patients. Singhi AD, Montgomery EA. Am J Surg Pathol. 2011 Feb;35(2):305-10. PMID: 21263252
