nodular scleroderma

Cutaneous scleroderma usually appears as sclerosis or atrophy. The occurrence of nodular lesions on systemic or localized scleroderma was first described in 1884 by Addison.

Clinically, it is a keloidal nodule developing on sclerosis. Histological pattern can mimic keloid or scleroderma. The exact etiology remains unknown and usual therapeutic is poorly effective.

Synopsis

 nodular cutaneous scleroderma (nodular scleroderma or keloidal scleroderma)

• systemic scleroderma with nodules
• Nodular lesions on systemic or localized scleroderma was first described in 1884 by Addison.
• Clinically, it is a keloidal nodule developing on sclerosis.
• Histological pattern can mimic keloid or scleroderma.
• The exact etiology remains unknown
• Usual therapeutic is poorly effective.

References

 Addison T. On keloid of Alibert and untrue keloid.Trans med Chir Soc Lond.1854

 Kubo M, Tamaki T, Fujimoto M, et al. Keloid like morphea. Acta Derm Venereol 1996;77:90-1

 Krell JM, Solomon AR, Glavey CM, Lawley TJ. Nodular scleroderma. J am Acad
Dermatol 1995; 32: 343-5

 Labandiera J, Leon-Mateos A, Suarez-Penaranda JM, Garea MT, et al. Polymorphic fibrosing reaction mimicking keloidal scleroderma but without associated classic scleroderma. Dermatology 2003; 207:204-5

 Barzilai A, Lyakholvitsky, Horowitz A, et al. Keloid-like scleroderma. Am J
Dermatopathol. 2003; 25: 327-330

 Wriston CC, Rubin AI, Elenitsas R, Crawford GH. Nodular scleroderma: a report of 2 cases. Am J Dermatopathol. 2008; 30: 385-8.

 Yamamoto T, Sawada Y, Katayama I, Nishioka K. Nodular scleroderma: increased expression of connective tissue growth factor. Dermatology. 2005; 211:218-23.