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depression
Friday 14 November 2003
Mood disorders, including major depressive disorder and bipolar disorder, are influenced by both genetic and environmental factors.
Hypotheses about the neurobiology of mood disorders have been postulated and putatively associated genes identified.
The immune-related gene encoding purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7) has been genetically associated with major depressive disorder and bipolar disorder.
New candidate genes and emerging gene networks and pathways involved in the aetiology of mood disorders point to a major role for neuronal survival and the adaptive immune systems.
Predisposition loci
12q22-12q23.2 (14606042)
References
Belmaker RH, Agam G. Major depressive disorder. N Engl J Med. 2008 Jan 3;358(1):55-68. PMID: 18172175
Harvey M, Belleau P, Barden N. Gene interactions in depression: pathways out of darkness. Trends Genet. 2007 Nov;23(11):547-56. PMID: 17963976
Camp NJ, Cannon-Albright LA. Dissecting the genetic etiology of major depressive disorder using linkage analysis. Trends Mol Med. 2005 Mar;11(3):138-44. PMID: 15760772
