INHA

IHCDB

Definition: Inhibin is a polypeptide hormone secreted by granulosa cells of the ovary and Sertoli cells of the testis.

The inhibin-alpha subunit is also expressed in other human tissues such as the prostate, brain, and adrenal cortex, as well as cells of the fetoplacental unit.

Immunochemistry

The alpha-inhibin immunohistochemical stain is used as a differential marker for adrenocortical tumors, placental and gestational trophoblastic lesions, and sex cord stromal tumors, such as granulosa cell tumors, luteinized thecomas, and Leydig cell tumors.

 pancreatic tumors

• In pancreatic tumors, positive staining was only reported in luteinizing cells of the ovarian-like stroma of mucinous cystic neoplasms.

 gonadal tumors

• sex cord stromal tumors (SCSTs)
• Sertoli cells in gonadoblastoma

 some carcinomas
 adrenal cortical tumors (12808065)

• adrenal cortical carcinoma

 hemangioblastoma (12883249)
 other tumors

IHC examples

 INHA+ sertoli cells in gonadoblastoma

• https://twitter.com/hematogones/status/863133218593263617

See also

 inhibins (INHs)

• INHA
• INHBs
  • INHBA
  • INHBB
  • INHBC

References

 Kosmahl M, Wagner J, Peters K, Sipos B, Kloppel G. Serous cystic neoplasms of the pancreas: an immunohistochemical analysis revealing alpha-inhibin, neuron-specific enolase, and MUC6 as new markers. Am J Surg Pathol. 2004 Mar;28(3):339-46. PMID: 15104296

 Hildebrandt RH, Rouse RV, Longacre TA. Value of inhibin in the identification of granulosa cell tumors of the ovary. Hum Pathol. 1997 Dec;28(12):1387-95. PMID: 9416696