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TOP1

20q12-q13.1 HGNC:11986 MIM.126420

TOP1 gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription.

This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA.

This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22.

See also

- TOPs

  • TOP2s
    • TOP2A
    • TOP2B

References

- Immunohistochemical study of DNA topoisomerase I, p53, and Ki-67 in uterine carcinosarcomas. Lee SJ, Kim HS, Kim HS, Chun YK, Hong SR, Lee JH. Hum Pathol. 2007 Aug;38(8):1226-31. PMID: #17490723#

- Immunohistochemical study of DNA topoisomerase I, DNA topoisomerase II alpha, p53, and Ki-67 in oral preneoplastic lesions and oral squamous cell carcinomas. Hafian H, Venteo L, Sukhanova A, Nabiev I, Lefevre B, Pluot M. Hum Pathol. 2004 Jun;35(6):745-51. PMID: #15188142#

- Topoisomerase I protein expression in primary colorectal cancer and lymph node metastases. Boonsong A, Curran S, McKay JA, Cassidy J, Murray GI, McLeod HL. Hum Pathol. 2002 Nov;33(11):1114-9. PMID: #12454816#

- Expression of DNA toposiomerase I and DNA topoisomerase II-alpha in testicular seminomas. Coleman LW, Perkins SL, Bronstein IB, Holden JA. Hum Pathol. 2000 Jun;31(6):728-33. PMID: #10872667#

- Expression of DNA topoisomerase I in neoplasms of the kidney: correlation with histological grade, proliferation, and patient survival. Gupta D, Bronstein IB, Holden JA. Hum Pathol. 2000 Feb;31(2):214-9. PMID: #10685636#