Home > E. Pathology by systems > Locomotory system > Bones > low-grade osteosarcomas
low-grade osteosarcomas
Thursday 8 July 2010
Parosteal osteosarcoma and low-grade central osteosarcoma are two types of low-grade osteosarcoma that show similar clinical behaviors, histological features, and genetic background (ie, amplified sequences of 12q13-15, including MDM2 and CDK4).
Low-grade osteosarcomas are often confused with benign lesions.
Types
parosteal osteosarcoma
low-grade central osteosarcoma
Immunochemistry
The combination of MDM2 or CDK4 shows 100% sensitivity and 97.5% specificity for the diagnosis of low-grade osteosarcoma. (20601938)
- MDM2 and CDK4 immunostains reliably distinguish low-grade osteosarcoma from benign histological mimics, and their combination may serve as a useful adjunct in this difficult differential diagnosis. (20601938)
References
Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics. Yoshida A, Ushiku T, Motoi T, Shibata T, Beppu Y, Fukayama M, Tsuda H. Mod Pathol. 2010 Jul 2. PMID: 20601938
Characterization of the 12q15 MDM2 and 12q13-14 CDK4 amplicons and clinical correlations in osteosarcoma. Mejia-Guerrero S, Quejada M, Gokgoz N, Gill M, Parkes RK, Wunder JS, Andrulis IL. Genes Chromosomes Cancer. 2010 Jun;49(6):518-25. PMID: 20196171
