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BK virus nephropathy

Friday 14 May 2010, by JA

BK virus nephropathy is not an infrequent complication of renal transplantation associated with high rates of graft loss.

BK virus immunochemistry

Although antibodies against SV40 antigen detect different viruses of the polyomavirus family, immunohistochemistry is widely used to confirm the diagnosis of BK virus nephropathy in renal biopsies.

BK virus SISH

BK virus SISH is an ancillary tool for the detection of polyomavirus DNA in renal biopsies using bright-field microscopy. However, its diagnostic value in comparison with standard immunohistochemistry seems to be limited. (21532490)

Digital cases

- Case 272 : BK Virus nephritis


- BK virus tubulitis

See also

- BK virus
- polyomavirus


- Silver-enhanced in situ hybridization for detection of polyomavirus DNA in patients with BK virus nephropathy. Fritzsche FR, Pianca S, Gaspert A, Varga Z, Wang L, Farrell MP, Chen XB, Hirsch HH, Springer E, Fehr T, Myles J, Tubbs R, Moch H. Diagn Mol Pathol. 2011 Jun;20(2):105-10. PMID: 21532490

- Update on human polyomavirus BK nephropathy. Cimbaluk D, Pitelka L, Kluskens L, Gattuso P. Diagn Cytopathol. 2009 Oct;37(10):773-9. PMID : 19626630

- Dendritic cell deficiency associated with development of BK viremia and nephropathy in renal transplant recipients. Womer KL, Huang Y, Herren H, Dibadj K, Peng R, Murawski M, Shraybman R, Patton P, Clare-Salzler MJ, Kaplan B. Transplantation. 2010 Jan 15;89(1):115-23. PMID: 20061927

- Polyomavirus nephropathy: a current perspective and clinical considerations. Wiseman AC. Am J Kidney Dis. 2009 Jul;54(1):131-42. PMID: 19394729

- The decade of polyomavirus BK-associated nephropathy: state of affairs. Ramos E, Drachenberg CB, Wali R, Hirsch HH. Transplantation. 2009 Mar 15;87(5):621-30. PMID: 19295303

- BK virus large T and VP-1 expression in infected human renal allografts. Seemayer CA, Seemayer NH, Dürmüller U, Gudat F, Schaub S, Hirsch HH, Mihatsch MJ. Nephrol Dial Transplant. 2008 Dec;23(12):3752-61. PMID: 18784088

- Polyomavirus in renal transplantation: a hot problem. Bonvoisin C, Weekers L, Xhignesse P, Grosch S, Milicevic M, Krzesinski JM. Transplantation. 2008 Apr 15;85(7 Suppl):S42-8. PMID: 18401263

- BK virus nephritis after renal transplantation. Dall A, Hariharan S. Clin J Am Soc Nephrol. 2008 Mar;3 Suppl 2:S68-75. PMID : 18309005

- Histologic versus molecular diagnosis of BK polyomavirus-associated nephropathy: a shifting paradigm? Drachenberg CB, Papadimitriou JC, Ramos E. Clin J Am Soc Nephrol. 2006 May;1(3):374-9. PMID : 17699234

- Primer: histopathology of polyomavirus-associated nephropathy in renal allografts. Liptak P, Kemeny E, Ivanyi B. Nat Clin Pract Nephrol. 2006 Nov;2(11):631-6. PMID: 17066055