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large cell calcifying Sertoli cell tumor
Monday 25 January 2010
Definition: Tumor originating from Sertoli cells are a rare subset of sex cord-stromal tumors comprising not more than 1% of all testicular tumors.
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large cell calcifying Sertoli cell tumour
Large cell calcifying Sertoli cell tumor (LCCSCT) is a distinct subtype of Sertoli cell tumors occurring almost invariably in the testis.
LCCSCT may be multicentric or bilateral and, as such, are frequently seen in association with Carney complex or Peutz-Jeghers syndrome.
Malignant behavior of LCCSCT is exceptionally rare.
Synopsis
Variant occurring in childhood
- average age 16 years
- sporadic and associated with Carney and Peutz–Jeghers syndromes
20% malignant
40% bilateral
Nests / cords of polygonal cells with eosinophilic cytoplasm
Myxoid / hyaline stroma
Foci of calcification
Note: calcification may be absent even though called LCCST.
See also
testicular sex cord-stromal tumors
References
Large cell calcifying Sertoli cell tumor: a clinicopathologic study of 1 malignant and 3 benign tumors using histomorphology, immunohistochemistry, ultrastructure, comparative genomic hybridization, and polymerase chain reaction analysis of the PRKAR1A gene. Petersson F, Bulimbasic S, Sima R, Michal M, Hora M, Malagon HD, Matoska J, Hes O. Hum Pathol. PMID: 20004940
