Home > D. General pathology > Blood and immunity > solitary form of Castleman disease
solitary form of Castleman disease
Wednesday 6 January 2010
Synopsis
Presents as a mass:
- most common in mediastinum
- also described in: neck, lung, axilla, mesentery, broad ligament, retroperitoneum, soft tissues of extremities, nasopharynx, meninges, several other sites
morphological types
- >90% are hyaline-vascular type Castleman disease: usually asymptomatic
- ≈10% plasma cell type Castleman disease: often associated with: fever, anemia, elevated erythrosedimentation rate, hypergammaglobulinemia, hypoalbuminemia
Sometimes microscopic changes suggesting early stage of same process in adjacent nodes
Macroscopy
Round
Well-circumscribed
Cut surface: solid, gray
can measure ≥15cm diameter
See also
Castleman disease
