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pulmonary lupus
Wednesday 6 January 2010
Pleuropulmonary manifestations of systemic lupus erythematosus (SLE) have been reported to be of variable prevalence.
Synopsis
pleuropulmonary involvement in 97.8% of autopsies (19762378)
pleuritis (77.8%)
bacterial infections (57.8%)
primary and secondary alveolar haemorrhages (25.6%)
distal airway alterations (21.1%)
opportunistic infections (14.4%)
pulmonary thromboembolism (7.8%), both acute and chronic.
acute lupus pneumonitis
chronic lupus pneumonitis
opportunistic pulmonary infections
- invasive aspergillosis
- disseminated strongyloidiasis
- mucormycosis
- Pneumocystis carinii
alveolar haemorrhage
capillaritis
primary pulmonary hypertension (PHT) with plexiform lesions
Sepsis is considered the major cause of death. Pulmonary manifestations directly caused by systemic lupus erythematosus are very uncommon and that their prevalence has not changed in the past 10 years. Pulmonary infection is still the most frequent affection, and it is an important cause of death in patients with lupus. (19762378)
References
Pulmonary involvement of systemic lupus erythematosus: analysis of 90 necropsies. Quadrelli SA, Alvarez C, Arce SC, Paz L, Sarano J, Sobrino EM, Manni J. Lupus. 2009 Oct;18(12):1053-60. PMID: 19762378
