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BRD4-NUT

Friday 4 December 2009

BRD4/NUT

Definition: The protein encoded by BRD4 is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Two alternatively spliced transcript variants have been described.

Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting.

Pathology

- BRD4-NUT poorly differentiated carcinomas ( BRD4-NUT midline carcinoma )

  • BRD4 has been implicated in translocation t(15;19)(q13;p13.1), which defines an upper respiratory tract carcinoma in young people : NUT midline carcinoma .
  • A subset of poorly differentiated carcinomas is characterized by the translocation t(15;19)(q13;p13), resulting in a BRD4/NUT fusion gene.
  • Typically, this tumor affects children or young adults, with a predilection for midline head and neck, thoracic structures, iliac bone.
  • The clinical course is invariably fatal, in spite of intensive chemotherapy and radiotherapy.
  • The t(15;19)-BRD4/NUT-positive tumors may arise in locations more typical for other pediatric tumors, such as Ewing sarcoma, and that they not always display epithelial differentiation.
  • Some patients with t(15;19)-positive tumors may be successfully treated.

See also

- BRD4/NUT-positive undifferentiated tumor
- NUT midline carcinomas
- NUT-associated carcinomas

References

- Successful treatment of a child with t(15;19)-positive tumor. Mertens F, Wiebe T, Adlercreutz C, Mandahl N, French CA. Pediatr Blood Cancer. 2007 Dec;49(7):1015-7. PMID: 16435379