neuropathic CIPO

Physiopathology

Activation of autoimmune pathways has been implicated as a contributing mechanism to the pathophysiology in some patients with chronic intestinal pseudoobstruction (CIP).

Antineuronal antibodies may contribute to neuronal dysfunction observed in a subset of patients with neurogenic CIP via autoantibody-mediated activation of autophagy involving the Fas receptor complex. (18582468)

Intestinal dysmotility is a component of many neurodegenerative disorders, including some characterized by neuronal intranuclear inclusions.

See also

 digestive neuropathies (enteric neuropathies)

References

 Neurogenic chronic intestinal pseudo-obstruction: antineuronal antibody-mediated activation of autophagy via Fas. de Giorgio R, Volta U, Stanghellini V, Cogliandro RF, Barbara G, Corinaldesi R, Towns R, Guo C, Hong S, Wiley JW. Gastroenterology. 2008 Aug;135(2):601-9. PMID: 18582468

 Visceral neuropathy and intestinal pseudo-obstruction in a murine model of a nuclear inclusion disease. Clarke CM, Plata C, Cole B, Tsuchiya K, La Spada AR, Kapur RP. Gastroenterology. 2007 Dec;133(6):1971-8. PMID: 18054568

 Human enteric neuropathies: morphology and molecular pathology. De Giorgio R, Camilleri M. Neurogastroenterol Motil. 2004 Oct;16(5):515-31. PMID: 15500508