absence of Cajal cells

Absence or altered distribution of the interstitial cells of Cajal (ICCs) has been described in association with intestinal pseudoobstruction in adults. Abnormalities of the ICCs in intestinal pseudoobstruction should be considered early in the diagnostic workup of children with intestinal pseudoobstruction. (19040916)

References

 Absence of the interstitial cells of Cajal in a child with chronic pseudoobstruction. Struijs MC, Diamond IR, Pencharz PB, Chang KT, Viero S, Langer JC, Wales PW. J Pediatr Surg. 2008 Dec;43(12):e25-9. PMID: 19040916

 Jain D, Moussa K, Tandon M, Culpepper-Morgan J, Proctor DD. Role of interstitial cells of Cajal in motility disorders of the bowel. Am J Gastroenterol. 2003 Mar;98(3):618-24. PMID: 12650797

 Pardi DS, Miller SM, Miller DL, Burgart LJ, Szurszewski JH, Lennon VA, Farrugia G. Paraneoplastic dysmotility: loss of interstitial cells of Cajal. Am J Gastroenterol. 2002 Jul;97(7):1828-33. PMID: 12135044

 Hassler WL. Is constipation caused by a loss of interstitial cells of Cajal? Gastroenterology 2003; 125:264-265.