nevoid melanoma

Definition : Nevoid melanoma may resemble benign compound or intradermal nevi by their silhouette and profile on low power. Higher power usually reveals nuclear atypia, confluence of cells, incomplete maturation and dermal mitotic activity.

Images

 Nevoid melanoma

• https://twitter.com/phmckee1948/status/882483859757166592
• https://twitter.com/MPLEEMD/status/1062734535408926722

However, to some extent all of these features maybe seen in benign compound or intradermal nevi and no single criteria can be used to differentiate nevoid melanoma from a benign nevus.

The distinction can be particularly problematic in nevi that show mitotic activity.

Dermal mitoses alone without other diagnostic features such as nuclear atypia and lack of maturation does not constitute sufficient evidence alone for a diagnosis of melanoma. (19809275)

See also

 malignant melanoma

• cutaneous melanoma

 melanocytic tumors

• melanocytic nevus / melanocytic nevi

Open references

 Nevoid melanoma of the vagina: report of one case diagnosed on thin layer cytological preparations. Fulciniti F, Ascierto PA, Simeone E, Bove P, Losito S, Russo S, Gallo MS, Greggi S. Cytojournal. 2007 Jul 3;4:14. PMID: 17608945 [Free]

References

 Recurrence of nevoid melanoma originally diagnosed as benign nevus. Collina G, Reggiani C. Pathologica. 2009 Jun;101(3):112-4. PMID: 19886544

 Fluorescence in Situ Hybridization for Distinguishing Nevoid Melanomas From Mitotically Active Nevi. Gerami P, Wass A, Mafee M, Fang Y, Pulitzer MP, Busam KJ. Am J Surg Pathol. 2009 Oct 3. PMID: 19809275