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DOG1

Monday 20 July 2009

Definition: Anoctamin-1 (ANO1) (DOG1, TMEM16a) is a calcium-activated chloride channel initially described in gastrointestinal stromal tumors, but now known to be expressed in a variety of normal and tumor tissues including salivary tissue in murine models.

Images

- Rectal leiomyosarcoma. More pleomorphic than GIST. Desmin+ Dog1-

Diagnostic use

- GIST / gastrointestinal stromal tumor

  • DOG1 expression in GIST
  • DOG1 is highly specific for GIST.
  • possible DOG1 positivity in other mesenchymal tumors included uterine type retroperitoneal leiomyomas, peritoneal leiomyomatosis, and synovial sarcomas.

- low-frade fibromyxoid sarcoma (LGFMS)

  • DOG1 expression in low-frade fibromyxoid sarcoma (26135531)

- leiomyomas

  • Leiomyomas colonized by DOG1-positive Cajal cells should not be confused with GISTs.

- digestive carcinomas

- slivary gland tumors

  • DOG1 is a marker of salivary acinar and intercalated duct differentiation (22460810)
  • DOG1 staining is a marker of salivary acinar and to a lesser extent intercalated duct differentiation.
  • DOG1 strong staining can be used to support the diagnosis of acinic cell carcinoma .
  • DOG1 may also be a marker of a ’transformed’ myoepithelial phenotype in a subset of biphasic salivary gland malignancies.
  • Image: https://twitter.com/CaryBureshMD/status/718543701614718977

References

- DOG1 Expression in Low-Grade Fibromyxoid Sarcoma: A Study of 11 Cases, With Molecular Characterization. Thway K, Ng W, Benson C, Chapman J, Fisher C. Int J Surg Pathol. 2015 Sep;23(6):454-60. doi : 10.1177/1066896915593801 PMID: 26135531

- DOG1 Antibody in the Differential Diagnosis of Gastrointestinal Stromal Tumors: A Study of 1840 Cases. Miettinen M, Wang ZF, Lasota J. Am J Surg Pathol. 2009 Jul 13. PMID: 19606013

- Monoclonal antibody DOG1.1 shows higher sensitivity than KIT in the diagnosis of gastrointestinal stromal tumors, including unusual subtypes. Liegl B, Hornick JL, Corless CL, Fletcher CD. Am J Surg Pathol. 2009 Mar;33(3):437-46. PMID: 19011564

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