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chondroblastic osteosarcoma

Tuesday 26 May 2009

Digital cases

- Case 115 : Chondroblastic osteosarcoma of the calcaneum

Definition : Chondroblastic osteosarcoma (OS) accounts for about 25% of all cases of OS.


- flat bones


Grossly, an overt chondroid appearance is rare. This is probably secondary to the cartilage component being less well-formed, high grade, and mixing with non-chondroid elements resulting in a lack of large areas of pure chondroid differentiation and its attendant blue-grey lobulated appearance.

Chondroblastic osteosarcomas tend to be white to tan, and variably calcified with a fish-flesh or rope-like cut surface.


Chondroid matrix is predominant in chondroblastic osteosarcoma.

Chondroid matrix tends to be high grade hyaline cartilage, which is intimately associated, and randomly mixed, with non-chondroid elements.

Myxoid and other forms of cartilage are uncommon, except in the jaws and pelvis.

Differential diagnosis

It can pose diagnostic difficulty on cytology, as the tumor cells may resemble the carcinomatous cells.


A chondroblastic subtype of osteosarcoma could be at risk to have a higher risk for late relapse. (16426841)

See also

- osteosarcomas

  • conventional osteosarcoma


- Galectin-1 is a powerful marker to distinguish chondroblastic osteosarcoma and conventional chondrosarcoma. Gomez-Brouchet A, Mourcin F, Gourraud PA, Bouvier C, De Pinieux G, Le Guelec S, Brousset P, Delisle MB, Schiff C. Hum Pathol. 2010 Sep;41(9):1220-30. PMID: 20399482

- Clinico-histologic parameters of osteosarcoma patients with late relapse. Hauben EI, Bielack S, Grimer R, Jundt G, Reichardt P, Sydes M, Taminiau AH, Hogendoorn PC. Eur J Cancer. 2006 Mar;42(4):460-6. PMID: 16426841