Home > E. Pathology by systems > Urinary system > Kidneys > renal cell tumors
renal cell tumors
Tuesday 26 May 2009
Types
papillary adenoma
renal oncocytoma
renal cell carcinomas
- clear cell renal cell carcinoma
- papillary renal cell carcinoma
- chromophobe renal cell carcinoma
- Bellini collecting ducts renal cell carcinoma
- renal medullary carcinoma
- TFE3-associated renal cell carcinoma (Xp11 translocation-associated renal cell carcinoma)
- TFEB-associated renal cell carcinoma
- TFEB-associated HMB45+ epithelioid renal tumor
Immunochemistry
Onc: Oncocytoma
ClC-RCC, EosinCytoplasm
Chromophobe Carcinoma, Eosinophilic Variant
EAML: Epithelioid Angiomyolipoma
PRCC2: Papillary RenalCell Carcinoma (Pap RCC), Type 2
TRCC: Translocation Carcinoma t(6:11)t(6;11)
CDC: Collecting DuctCarcinoma
MC: Medullary Carcinoma
TCC: TubulocysticCarcinoma
TMSCC: Tubular Mucinous Spindle Cell Carcinoma
| Antibody | Onc. | ClC-RCC | ChC-RCC | EAML | PRCC2 | TRCC | CDC | MC | TCC | TMSCC | |||||||||||
| CAM 5.2 | pos | pos | pos | neg | pos | neg | pos | pos | pos | pos | |||||||||||
| AE1/AE3 | pos | pos | pos | neg | pos | neg | pos | pos | pos | pos | |||||||||||
| Vimentin | neg | pos | neg | neg | pos | pos | pos | pos | - | pos | |||||||||||
| EMA | pos | pos | pos | neg | pos | neg | pos | pos | - | pos | |||||||||||
| CD10 | pos/neg | pos | pos/neg | neg | pos | pos | pos/neg | - | pos | pos/neg | |||||||||||
| RCC Ma | neg | pos | neg | neg | pos/neg | - | - | - | - | neg | |||||||||||
| CK7 | “patchy” | neg | pos | neg | pos | neg | pos | pos | pos | pos | |||||||||||
| CK20 | neg | neg | neg | neg | neg | neg | neg | neg | neg | neg | |||||||||||
| CK19 | neg | neg | neg | neg | neg | pos/neg | pos | pos | pos/neg | pos | 34BE12 | neg | neg | neg | neg | pos/neg | neg | pos/neg | neg | pos/neg | pos/neg |
| AMACR | neg | neg | neg | - | pos | pos | neg | - | pos | pos | |||||||||||
| Parvalbumin | pos | neg | pos | - | neg | - | - | - | pos | - | S100A1 | pos | pos | neg | - | pos | - | - | - | - | - |
| C-kit | pos | neg | pos | neg | pos/neg | - | pos/neg | - | - | neg |
E-cadherin pos neg pos - pos/neg pos pos - - -
Kid sp cad pos neg pos - neg neg neg neg neg neg
Caveolin-1 neg - pos - - - - - - -
Cathepsin K neg neg neg - neg pos - - - -
PAX-2 pos pos neg - pos/neg neg neg - pos pos/neg
TFE3 neg neg pos - neg pos - - - -
TFEB neg neg - - neg neg - - - -
UEA-1 neg neg - - pos/neg - pos - pos -
HMB 45 neg neg neg pos neg neg neg neg neg neg
Melan A neg neg neg pos neg neg neg neg neg neg
Coll iron neg neg pos - neg neg neg neg neg neg
Links
Renal Neoplasms: An Update on Immunohistochemical and Histochemical Features by Dako
References
The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. Srigley JR, Delahunt B, Eble JN, Egevad L, Epstein JI, Grignon D, Hes O, Moch H, Montironi R, Tickoo SK, Zhou M, Argani P; The ISUP Renal Tumor Panel. Am J Surg Pathol. 2013 Oct;37(10):1469-1489. PMID: 24025519
Molecular approaches to classify adult renal epithelial neoplasms. Maj M, Wagner L. Expert Rev Mol Diagn. 2011 Nov;11(8):803-6. PMID: 22022942
Molecular classification of adult renal epithelial neoplasms using microRNA expression and virtual karyotyping. Powers MP, Alvarez K, Kim HJ, Monzon FA. Diagn Mol Pathol. 2011 Jun;20(2):63-70. PMID: 21532496
Virtual-Karyotyping With SNP Microarrays in Morphologically Challenging Renal Cell Neoplasms: A Practical and Useful Diagnostic Modality. Kim HJ, Shen SS, Ayala AG, Ro JY, Truong LD, Alvarez K, Bridge JA, Gatalica Z, Hagenkord JM, Gonzalez-Berjon JM, Monzon FA. Am J Surg Pathol. 2009 May 20. PMID: 19461508
