ovarian tumors with prominent spindle cells

Etiology

 Primary Ovarian Tumors With Prominent Spindle Cells

• ovarian fibromatous tumors (typical, cellular, mitotically active, and fibrosarcomas)
• ovarian sex cord-stromal tumors
• ovarian malignant mixed mesodermal tumors
• ovarian endometrioid carcinoma
• ovarian endometrioid stromal sarcoma
• ovarian sarcomatoid foci in mucinous tumors
• ovarian myxoma
• miscellaneous others

 Metastatic Ovarian Tumors With Prominent Spindle Cells

• metastatic endometrial stromal sarcoma
• metastatic Gastrointestinal stromal tumors (GIST)
• metastatic malignant melanoma (infrequently)

References

 1. Tornos C, Silva EG, Ordonez NG, Gershenson DM, Young RH, Scully RE. Endometrioid carcinoma of the ovary with a prominent spindle-cell component, a source of diagnostic confusion. A report of 14 cases. Am J Surg Pathol 19: 1943-1353, 1995.

 2. Young, RH, Scully RE. Differential diagnosis of the ovarian tumors based primarily on their patterns and cell types. Semin Diagn Pathol 18, 161-235, 2001.

 3. Irving JA, McCluggage WG. Ovarian spindle cell lesions. A review with emphasis on recent developments and differential diagnosis. Adv Anat Pathol 14:305-319, 2007.

 4. Young RH, Prat J, Scully RE. Endometrioid stromal sarcomas of the ovary. A clinicopathologic analysis of 23 cases. Cancer 53:1143-1155, 1984.

 5. Young RH, Scully RE. Sarcomas metastatic to the ovary: A report of 21 cases. Int J Gynecol Pathol 9:231-252, 1990.

 6. Provenza C, Young RH, Prat J. Anaplastic carcinoma in mucinous ovarian tumors. A clinicopathologic study of 34 cases emphasizing the crucial impact of stage on prognosis, their histologic spectrum, and overlap with sarcomalike mural nodules. Am J Surg Pathol 32:383-389, 2008.

 7. Irving JA, Lerwill MF, Young RH. Gastrointestinal stromal tumors metastatic to the ovary. A report of five cases. Am J Surg Pathol 29:920-926, 2005.