primary CIPO

Definition: Primitive chronic intestinal pseudoobstruction (primitive CIPO) is classified into enteric visceral myopathies, neuropathies, and/or mesenchymopathies. Although the histology usually permits to highlight pathologic abnormalities of CIPO, it fails in almost a third of cases.

Types

 myopathic CIPO (enteric visceral myopathies)
 neuropathic CIPO or neurogenic CIPO (enteric visceral neuropathies)
 mesenchymopathic CIPO (enteric visceral mesenchymopathies)
 absence of the interstitial cells of Cajal (19040916)

Immunochemistry

Immunohistochemistry using Hu C/D and CD117 antibodies combined to the standard histology increased the yield of detection of neuromuscular abnormalities in idiopathic CIPO patients. (19252433)

Animal models

 Deletion of PTEN in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction. (19884655)

See also

 chronic intestinal pseudoobstruction (CIPO)

Reviews

 Wingate D, Hongo M, Kellow J, et al. Disorders of gastrointestinal motility: towards a new classification. J Gastroenterol Hepatol 2002; 17:S1-14.

References

 Intestinal transplantation for motility disorders. Millar AJ, Gupte G, Sharif K. Semin Pediatr Surg. 2009 Nov;18(4):258-62. PMID: 19782308

 Deletion of Pten in the mouse enteric nervous system induces ganglioneuromatosis and mimics intestinal pseudoobstruction. Puig I, Champeval D, De Santa Barbara P, Jaubert F, Lyonnet S, Larue L. J Clin Invest. 2009 Nov 2. PMID: 19884655

 Absence of the interstitial cells of Cajal in a child with chronic pseudoobstruction. Struijs MC, Diamond IR, Pencharz PB, Chang KT, Viero S, Langer JC, Wales PW. J Pediatr Surg. 2008 Dec;43(12):e25-9. PMID: 19040916

 The role of immunohistochemistry in idiopathic chronic intestinal pseudoobstruction (CIPO): a case-control study. Amiot A, Cazals-Hatem D, Joly F, Lavergne-Slove A, Peuchmaur M, Bouhnik Y, Bedossa P, Messing B. Am J Surg Pathol. 2009 May;33(5):749-58. PMID: 19252433

 Chronic intestinal pseudoobstruction: report of four pediatric patients. Dalgiç B, Sari S, Doğan I, Unal S. Turk J Gastroenterol. 2005 Jun;16(2):93-7. PMID: 16252200