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mammary cribriform carcinoma

Sunday 2 April 2017

Cribriform carcinoma of the breast; mammary invasive cribriform carcinoma; ICC

Infiltrating cribriform carcinoma (ICC) of the breast, which is characterized by a predominant cribriform growth pattern of its invasive component, is a distinct histological type of invasive carcinoma first described by Page et al in 1983.

The incidence of ICC is reported to range from 0.3 to 3.5%. The carcinoma has a low frequency of axillary nodal metastases and a favorable prognosis.

Immunohistochemical studies have revealed that the majority of patients with ICC exhibited estrogen receptor (ER) and progesterone receptor (PR) positive tumors, while human epidermal growth factor receptor 2 (HER2) amplification was rarely observed. F

or this reason, some people recommended that this favorable histotype with luminal tumor may be suitable for no therapy or endocrine therapy alone.

Cribriform carcinoma does not have myoepithelial cells or basement membrane material. It is CD117 negative. It is positive for ER. It is associated with and histologically appears similar to cribriform DCIS, but is invasive.

ICC of the breast is characterized by a predominant cribriform growth pattern of its invasive component according to the new definition by the WHO and the description by Page et al from 1983.

Pure ICC is defined as being almost entirely (>90%) of an invasive cribriform pattern, while lesions that demonstrate a predominantly cribriform differentiation with the remaining component limited to a tubular carcinoma (TC) pattern are also included in the category of ICC.

Cases with a component that is @<@50% of a carcinoma type other than TC should be regarded as a mixed type of ICC.

In histopathological specimens, this type of carcinoma must be distinguished from other invasive breast carcinomas that exhibit a cribriform pattern, including adenoid cystic carcinoma.

Immunocytochemical staining for basement membrane materials or an ultrastructural examination is recommended when accurate diagnosis is difficult.

In the cases of the present study, it was observed that 50% of patients could not be correctly diagnosed by intraoperative frozen section, while H&E staining and immunohistochemistry were able to confirm all cases.



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