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pancreatic development
Wednesday 29 October 2003
Molecular signaling pathways
| FOXA2 | IPF1 |
Differentiation of early foregut endoderm into pancreatic endocrine and exocrine cells depends on a cascade of gene activation events controlled by various transcription factors.
The forkhead/winged helix transcription factor FOXA2 (formerly HNF-3beta) is a major upstream regulator of IPF1 (human homolog of murine Pdx1), a homeobox gene essential for pancreatic development.
IPF1 is also essential for the maintenance of glucose homeostasis.
Pathology
anomalies of pancreatic organogenesis (pancreatic dysplasia)
Features
FOXA2/IPF1 regulatory cascade during pancreatic beta-cell differentiation
References
Edlund H. Pancreatic organogenesis—developmental mechanisms and implications for therapy. Nat Rev Genet. 2002 Jul;3(7):524-32. PMID: 12094230
