pancreatic ductal adenocarcinoma

Definition: Pancreatic ductal adenocarcinoma is a highly aggressive, lethal human malignancy that continues to elude successful treatment. Although most patients present with metastatic disease, the molecular pathways that underlie tumor progression and metastases are poorly understood.

Images

 FNA of PDAC

• https://twitter.com/marthabpitman/status/745652503660879874
• https://twitter.com/marthabpitman/status/746029442678530048

Prognosis

 Perineural and intraneural invasion in posttherapy pancreaticoduodenectomy specimens predicts poor prognosis in patients with pancreatic ductal adenocarcinoma. (22301497)

 Tumor invasion of muscular vessels predicts poor prognosis in patients with pancreatic ductal adenocarcinoma who have received neoadjuvant therapy and pancreaticoduodenectomy. (22301496)

Miscellaneous

 HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma. Some results support role for HMGA2 in the progression of pancreatic ductal adenocarcinoma and suggest that it could be a useful biomarker and rational therapeutic target in more advanced disease. (18843278)

Links

 Nomenclature for Classification of Duct Lesions in the Pancreas (NCI, 1999) at Hopkins

Open references

 The complexity of pancreatic ductal cancers and multidimensional strategies for therapeutic targeting. Kern SE, Shi C, Hruban RH. J Pathol. 2011 Jan;223(2):295-306. doi : 10.1002/path.2813
PMID: 21125682

References

 Perineural and intraneural invasion in posttherapy pancreaticoduodenectomy specimens predicts poor prognosis in patients with pancreatic ductal adenocarcinoma. Chatterjee D, Katz MH, Rashid A, Wang H, Iuga AC, Varadhachary GR, Wolff RA, Lee JE, Pisters PW, Crane CH, Gomez HF, Abbruzzese JL, Fleming JB, Wang H. Am J Surg Pathol. 2012 Mar;36(3):409-17. PMID: 22301497

 Tumor invasion of muscular vessels predicts poor prognosis in patients with pancreatic ductal adenocarcinoma who have received neoadjuvant therapy and pancreaticoduodenectomy. Chatterjee D, Rashid A, Wang H, Katz MH, Wolff RA, Varadhachary GR, Lee JE, Pisters PW, Gomez HF, Abbruzzese JL, Fleming JB, Wang H. Am J Surg Pathol. 2012 Apr;36(4):552-9. PMID: 22301496

 The number of lymph nodes identified in a simple pancreatoduodenectomy specimen: comparison of conventional vs orange-peeling approach in pathologic assessment. Adsay NV, Basturk O, Altinel D, Khanani F, Coban I, Weaver DW, Kooby DA, Sarmiento JM, Staley C. Mod Pathol. 2008 Sep 26. PMID: 18820663

 Hristov AC, Cope L, Reyes MD, Singh M, Iacobuzio-Donahue C, Maitra A, Resar LM. HMGA2 protein expression correlates with lymph node metastasis and increased tumor grade in pancreatic ductal adenocarcinoma.Mod Pathol. 2008 Aug 29. PMID: 18843278