WDLPS/DDLPS
Well-differentiated and dedifferentiated liposarcomas (WDLPS/DDLPS) contain amplified sequences from the 12q13-15 region, including the MDM2 and CDK4 genes.
The detection of MDM2 and CDK4 expression or amplification is now a reliable tool for distinguishing benign adipose tissue tumors from WDLPS, and DDLPS from poorly differentiated tumors.
See also
well-differentiated liposarcomas (WDLPS)
dedifferentiated liposarcomas (DDLPS)