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WDLPS/DDLPS

Well-differentiated and dedifferentiated liposarcomas (WDLPS/DDLPS) contain amplified sequences from the 12q13-15 region, including the MDM2 and CDK4 genes.

The detection of MDM2 and CDK4 expression or amplification is now a reliable tool for distinguishing benign adipose tissue tumors from WDLPS, and DDLPS from poorly differentiated tumors.

See also

- well-differentiated liposarcomas (WDLPS)
- dedifferentiated liposarcomas (DDLPS)