NFIB

Pathology

  lipomas

• NFIB rearrangement in superficial, retroperitoneal, and colonic lipomas with aberrations involving chromosome band 9p22. (18663748)
• Lipomas are frequently characterized by rearrangements resulting in the fusion of the HMGA2 gene (12q14.3) with a variety of partners.
• Chromosome band 9p22 rearrangements occur in about 1% of lipomas.

 MYB-NFIB gene fusion in adenoid cystic carcinoma (ACC)

• Recurrent fusion of the v-myb avian myelobastosis viral oncogene homolog (MYB) and nuclear factor I/B (NFIB) generates the MYB-NFIB transcription factor, which has been detected in a high percentage of individuals with adenoid cystic carcinoma (ACC).
• mammary adenoid cystic carcinoma of the breast (MACC) (25217885)
• salivary adenoid cystic carcinoma of the breast (SACC)

 Transcription Factor NFIB Is a Driver of Small Cell Lung Cancer Progression in Mice and Marks Metastatic Disease in Patients.

• Small cell lung cancer (SCLC) is the most aggressive subtype of lung cancer and is characterized by early metastatic spread to multiple organs (Byers and Rudin, 2015).
• It is most often diagnosed at an advanced stage of disease and is generally fatal within 4 months if left untreated.
• Another striking feature of SCLC is its exceptional initial response to standard first line chemotherapy regimens, which is followed by rapid relapse of chemoresistant tumors, limiting the survival benefit for SCLC patients (Byers and Rudin, 2015).
• Due to its metastatic nature at presentation, SCLC is rarely resected, leading to a scarcity of tumor material for analysis.
• http://www.cell.com/cell-reports/fulltext/S2211-1247(16)30760-4

Paywall References

 MYB-NFIB gene fusion in adenoid cystic carcinoma of the breast with special focus paid to the solid variant with basaloid features. D’Alfonso TM, Mosquera JM, MacDonald TY, Padilla J, Liu YF, Rubin MA, Shin SJ. Hum Pathol. 2014 Nov;45(11):2270-80. doi : 10.1016/j.humpath.2014.07.013
PMID: 25217885

 Italiano A, Ebran N, Attias R, Chevallier A, Monticelli I, Mainguené C, Benchimol D, Pedeutour F. NFIB rearrangement in superficial, retroperitoneal, and colonic lipomas with aberrations involving chromosome band 9p22. Genes Chromosomes Cancer. 2008 Nov;47(11):971-7. PMID: 18663748