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Home > E. Pathology by systems > Reproductive system > Male genital system > gynecomastia


Tuesday 30 September 2008


Definition: Gynecomastia is a common disorder of the endocrine system in which there is a non-cancerous increase in the size of breast tissue in males.


Gynecomastia has ductal proliferation with a prominent rim of edematous stroma.


Differential diagnosis: mammary biphasic lesions

- adenomyoepithelioma
- mammary fibroadenomas

  • mammary juvenile fibroadenoma

- mammary hamartoma
- metaplastic mammary carcinoma
- phyllodes tumor
- pleomorphic adenoma
- gynecomastia
- pubertal macromastia


- The 3-layered Ductal Epithelium in Gynecomastia. Kornegoor R, Verschuur-Maes AH, Buerger H, van Diest PJ. Am J Surg Pathol. 2012 Feb 3. PMID: 22314184

- Braunstein GD. Clinical practice. Gynecomastia. N Engl J Med. 2007 Sep 20;357(12):1229-37. PMID: 17881754