DPYSL5
MIM.608383 2p23.3
The collapsin response mediator protein family (CRMPs) is involved in an autoimmune disease associated with small cell lung carcinoma.
Members of the CRMP family, such as DPYSL5, are believed to play a role in growth cone guidance during neural development.
Pathology
Strong and extensive CRMP5 expression is seen in 98.6% of high-grade neuroendocrine lung tumors, including small cell lung carcinoma and large cell lung neuroendocrine carcinoma, but not in any of the squamous cell carcinomas or lung adenocarcinomas in our series. (#18769332#)
In contrast, the majority of low-grade neuroendocrine lung tumors are negative for CRMP5 staining, although weak CRMP5 expression was seen in some, with 2 different staining patterns of either scattered positive cells or small foci of positive cells. (#18769332#)
CRMP5 is a novel marker for routine pathologic evaluation of lung tumors surgical samples in distinguishing between highly aggressive neuroendocrine carcinoma and the other lung cancers. (#18769332#)
References
Meyronet D, Massoma P, Thivolet F, Chalabreysse L, Rogemond V, Schlama A, Honnorat J, Thomasset N. Extensive Expression of Collapsin Response Mediator Protein 5 (CRMP5) is a Specific Marker of High-grade Lung Neuroendocrine Carcinoma. Am J Surg Pathol. 2008 Aug 30. PMID: #18769332#