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lobular endocervical glandular hyperplasia
Wednesday 24 September 2008
Lobular endocervical glandular hyperplasia (LEGH) was originally described as a distinct hyperplastic glandular lesion of the uterine cervix.
However, LEGH may be a cancerous precursor of minimal deviation adenocarcinoma (MDA) and other mucinous adenocarcinomas (MACs) of the uterine cervix. There is a molecular-genetic link between LEGH and cervical mucinous glandular malignancies including MDA and MAC, and a proportion of LEGHs could be cancerous precursors of MDA and/or MAC. (18779726)
References
Kawauchi S, Kusuda T, Liu XP, Suehiro Y, Kaku T, Mikami Y, Takeshita M, Nakao M, Chochi Y, Sasaki K. Is Lobular Endocervical Glandular Hyperplasia a Cancerous Precursor of Minimal Deviation Adenocarcinoma?: A Comparative Molecular-genetic and Immunohistochemical Study. Am J Surg Pathol. 2008 Sep 5. PMID: 18779726
