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acute coronary syndromes
Monday 22 September 2008
Classic environmental risk factors for atherosclerosis only partly explain the incidence of coronary artery disease and the development of acute coronary syndromes.
Genetic factors that vary among human populations seem to be involved in the clinical manifestations of such patients.
Substantial data suggest that a significant proportion of genetic polymorphisms involved in endothelial function, inflammation, lipid metabolism, thrombosis and fibrinolysis are often present in patients with acute coronary syndromes.
Susceptibility loci
9p21 region
References
Tousoulis D, Briasoulis A, Papageorgiou N, Antoniades C, Stefanadis C. Candidate gene polymorphisms and the 9p21 locus in acute coronary syndromes. Trends Mol Med. 2008 Sep 9. PMID: 18786860
