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STATs
Wednesday 29 October 2003
Definition: The signal transducer and activator of transcription (STATs) proteins are latent cytoplasmic signal-dependent transcription-factor pathways. In addition to several roles in normal cell decisions, dysregulation of STAT function contributes to human disease.
Members
| STAT1 | STAT2 | STAT3 | STAT4 | STAT5 | STAT6 |
IHC Markers
STAT6 in solitary fibrous tumor
See also
JAKs
JAKs/STATs signaling pathways
References
Clevenger CV. Roles and regulation of stat family transcription factors in human breast cancer. Am J Pathol. 2004 Nov;165(5):1449-60. PMID: 15509516
Yu H, Jove R. The STATs of cancer—new molecular targets come of age. Nat Rev Cancer. 2004 Feb;4(2):97-105. PMID: 14964307
Battle TE, Frank DA. The role of STATs in apoptosis. Curr Mol Med. 2002 Jun;2(4):381-92. PMID: 12108949
Aaronson DS, Horvath CM. A road map for those who don’t know JAK-STAT. Science. 2002 May 31;296(5573):1653-5. PMID: 12040185
Levy DE, Darnell JE Jr. Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol. 2002 Sep;3(9):651-62. PMID: 12209125
