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prostatic central zone
Monday 21 July 2008
The prostatic central zone (PCZ) is located at the base of the prostate adjacent to the seminal vesicles. Its histology is a potential mimicker of high-grade prostatic intraepithelial neoplasia (PIN).
CZ histology is distinctive. Recognition of the distinctive features of CZ histology (i.e., tall columnar cells with eosinophilic cytoplasm, prominent basal cell layer, and lack of cytologic atypia) can help avoid a misdiagnosis of PIN or "atypia" on needle biopsy (12094377).
Images
glands of central zone at the base of the prostate
- http://www.webpathology.com/image.asp?n=15&Case=19
- http://www.webpathology.com/image.asp?n=16&Case=19
Features (12094377)
eosinophilic cytoplasm (97%)
location at the end of a core (97%)
Roman arch formation (59%)
prominent basal cell layer (32%)
cribriform formation (26%
associated thick muscle bundles typical of bladder neck (24%)
References
Srodon M, Epstein JI. Central zone histology of the prostate: a mimicker of high-grade prostatic intraepithelial neoplasia. Hum Pathol. 2002 May;33(5):518-23. PMID: 12094377
