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modularity

Friday 11 July 2008

A network of interactions is called modular if it is subdivided into relatively autonomous, internally highly connected components. Modularity has emerged as a rallying point for research in developmental and evolutionary biology (and specifically evo-devo), as well as in molecular systems biology.

Types

- functional modularity
- disease modularity
- oncogenic modularity (tumoral modularity )

See also

- disease module

Reviews

- Oti M, Brunner HG. The modular nature of genetic diseases.Clin Genet. 2007 Jan;71(1):1-11. PMID: 17204041

- Simpson P. The stars and stripes of animal bodies: evolution of regulatory elements mediating pigment and bristle patterns in Drosophila. Trends Genet. 2007 Jul;23(7):350-8. PMID: 17499383

- Wagner GP, Pavlicev M, Cheverud JM. The road to modularity. Nat Rev Genet. 2007 Dec;8(12):921-31. PMID: 18007649

- Chen Y, Dokholyan NV. The coordinated evolution of yeast proteins is constrained by functional modularity. Trends Genet. 2006 Aug;22(8):416-9. PMID: 16797778

References

- A DIseAse MOdule Detection (DIAMOnD) algorithm derived from a systematic analysis of connectivity patterns of disease proteins in the human interactome. Ghiassian SD, Menche J, Barabási AL. PLoS Comput Biol. 2015 Apr 8;11(4):e1004120. doi : 10.1371/journal.pcbi.1004120 eCollection 2015 Apr. PMID: 25853560

- Disease networks. Uncovering disease-disease relationships through the incomplete interactome. Menche J, Sharma A, Kitsak M, Ghiassian SD, Vidal M, Loscalzo J, Barabási AL. Science. 2015 Feb 20;347(6224):1257601. doi : -10.1126/science.1257601 PMID: 25700523

- A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma. Sharma A, Menche J, Huang CC, Ort T, Zhou X, Kitsak M, Sahni N, Thibault D, Voung L, Guo F, Ghiassian SD, Gulbahce N, Baribaud F, Tocker J, Dobrin R, Barnathan E, Liu H, Panettieri RA Jr, Tantisira KG, Qiu W, Raby BA, Silverman EK, Vidal M, Weiss ST, Barabási AL. Hum Mol Genet. 2015 Jun 1;24(11):3005-20. doi : 10.1093/hmg/ddv001 PMID: 25586491