glomerular lesions

Types

 glomerular cellular alterations

• turgescent glomerular cells
  • turgescent endothelial cells (glomerular endotheliosis)
    • gravidic toxemia

• podocyte clarification
• lipidic deposits
  • mesangiolipidosis (lipid overload in mesangial cells)
    • L-acetycholesterol transferase deficiency (LCAT deficiency)
    • Alagille syndrome

• minimal glomerular lesions
• bilirubine in podocytes

• lipid overload in podocytes
  • Fabry disease

 glomerular cellularity anomalies

• endocapillary proliferation
  • segmental/global
  • focal/diffuse

• extracapillary proliferation
• endo-extracapillary proliferation

 glomerular capillary basal membrane anomalies
 mesangial matricx anomalies
 glomerular size anomalies
 glomerular shape anomalies

 retracted tuft

• retracted tuft with adhesion

 glomerular fibrous crescent
 periglomerular fibrosis

 tubulointerstitial lesions
 glomerular crescents (segmental/circonferential)

• ceullar
• fibrocellular

 abnormal glomerular deposits

• extramembranous deposits
  • small, regular (IgG)
  • bulky, bumps (C3, IgG)
• endomembranous deposits
  • sub-endothelial (IgG, IgM, C3)
  • mesangial (IgA, IgG, C3)

• intracapillary deposits (IgM, IgG)
• intracapillary thrombi (fibrin)

 intramembrabnous deposits (dense deposits)
 linear deposits (anti-glomerular basal membrane deposits)
 amyloid deposits
 hyalin deposits
 proteic thrombi

• cryoglobulinemia

Immunofluorescence - Immunochemistry

positive immune complexes