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metanephric adenofibroma

Monday 27 October 2003

Microscopical synopsis

- intratumoral angiodysplasia
- concentric cuffing of entrapped tubules ("onion skinning")
- heterologous differentiation
- epithelial components

  • inactive embryonal epithelium (identical morphologically to metanephric adenoma (MA)
  • carcinomatous component distinct from these lesions but identical morphologically to papillary renal cell carcinoma (PRCC).


- metastases to the regional lymph nodes at the time of diagnosis (1/9) (11257617)

Differential diagnosis

- congenital mesoblastic nephroma (CMN) -> intratumoral angiodysplasia, concentric cuffing of entrapped tubules ("onion skinning"), and heterologous differentiation. (11257617)

See also

- Tumors

  • renal tumors

- metanephric adenoma


- Arroyo MR, Green DM, Perlman EJ, Beckwith JB, Argani P. The spectrum of metanephric adenofibroma and related lesions: clinicopathologic study of 25 cases from the National Wilms Tumor Study Group Pathology Center. Am J Surg Pathol. 2001 Apr;25(4):433-44. PMID: 11257617