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damaged proteins

Cellular defense mechanisms against damaged proteins

- molecular chaperones for refolding and solubility modulation

  • HSP40
  • HSP70
  • HSP90

- ubiquitin-proteasome pathway (UPP) for degradation into aminoacids

  • ubiquitin conjugates, enzymes E1, E2, E3
  • proteasome chamber: 20S, 19S

- antioxydants enzymes