myxoid tumors

Digital cases

 HPC:11366: Primitive myxoid mesenchymal tumor of infancy (PMMTI).
 PDX:11322
 JRC:2276 : Soft tissueas (thigh). Intramuscular myxoma.
 JRC:3186 : Peritoneum : Pseudomyxoma peritonei.
 JRC:10739 : Cutaneous neurothekeoma.
 JRC:14664 : Soft tissue, wrist: Neurothekeoma/ Nerve sheath myxoma.

Examples

 Circumscribed myxoid lesion of finger

• http://www.flickr.com/photos/euthman/sets/72157629787295896/ by Ed Euthman

 Neurothekeoma

• http://www.flickr.com/photos/euthman/sets/72157629161850048/with/6813033020/ by Ed Euthman.

 extraskeletal myxoid chondrosarcoma

• https://twitter.com/histiocytosisX/status/715884176688484352

 acral myxoinflammatory fibroblastic sarcoma (12536311)

• image : https://twitter.com/RCarrMD/status/689657227645435904

 giant cell fibroblastoma

• https://twitter.com/JCandidoXavier/status/1188771734767460352

Definition: Tumors with myxoid background or tumors with myxoid stroma.

Localization

 myxoid soft tissue tumors / myxoid tumors of soft tissue
 cutaneous myxoid tumors

Types

• myxoma
  • odontogenic myxoma
  • intramuscular myxoma (9777984)
  • nerve-sheath myxoma (perineurial myxoma) (4091218)
  • myxoma of soft tissue Case PathDx #11322
    • cellular myxoma of soft tissue (11532040)

• myxofibrosarcoma
  • Images : https://twitter.com/histiocytosisX/status/759079650895200257

• myxosarcoma
• myxoid nervous tumors
  • myxoid neurofibroma
  • myxoid nerve sheath tumour
  • myxoid neurothekeoma ( nerve sheath myxoma )

• angiomyxoma
• fibromyxoid sarcoma
  • low grade fibromyxoid sarcoma
    • Image: https://twitter.com/KUSAURAP/status/713558502665400320

• ossifying fibromyxoid tumor (S100+)
  • Image: https://twitter.com/histiocytosisX/status/715902081031348224

• superficial acral fibromyxoma (11486169)
  • https://twitter.com/LinskeyKaty/status/733018339065401344

• acral myxoinflammatory fibroblastic sarcoma (12536311)
  • image : https://twitter.com/RCarrMD/status/689657227645435904

• myxoid leiomyoma
• myxoid chondrosarcoma
  • Image: https://twitter.com/histiocytosisX/status/715884176688484352

• myxoid liposarcoma
• botryoid-type of embryonal rhabdomyosarcoma
• myxoid malignant fibrous histiocytoma
• primitive myxoid mesenchymal tumor of infancy (PMMTI) (HP.9635)
• myxoid variant of follicular dendritic cell sarcoma (10196389)
• myxoid melanoma (11807440, 9711669)
• epithelioid hemangioendothelioma with myxoid features
  • image: https://twitter.com/histiocytosisX/status/718542603520765952

 myxoid tumors of bone

• chordoma and parachordome
• chondromyxoid fibroma of bone (CMF)

 myxoid tumors of the jaws

• odontogenic myxoma

Differential diagnosis

 myxoid lesions / myxoid anomalies
 clear cells in myxoid stroma

According to grade

 low-grade myxoid tumors
 high-grade myxoid tumors

Types

 fibromyxoid tumors

According to localization

 cutaneous myxoid tumors
 myxoid tumors of soft tissue
 myxoid tumors of bone

Immunochemistry

 CD34+ myxoid tumors

Videos

 cutaneous myxoid tumors by Steve D. Billings

• https://youtu.be/3LzQlAs_t0E

See also

 fibromyxoid tumors
 angiomyxoid tumors
 myxoinflammatory tumors

References

 Histopathol 2014 ; 64 : 1-170

 Mod Pathol 2014 ; 27 : S1-S112

 Graadt van Roggen J.F., Hogendoorn P.C.W., Fletcher C.D.M. Myxoid tumors of soft tissue Histopathol 1999 ; 35 : 291-312

 Ninfo V V, Montesco MC. Myxoid tumors of soft tissues: a challenging pathological diagnosis. Adv Clin Path. 1998 Apr;2(2):101-115. PMID: 10358337

 Wakely PE Jr. Myxomatous soft tissue tumors: correlation of cytopathology and histopathology. Ann Diagn Pathol. 1999 Aug;3(4):227-42. PMID: 10459049

 Mackenzie DH. The myxoid tumors of somatic soft tissues. Am J Surg Pathol. 1981 Jul;5(5):443-58. PMID: 6269445