rod PDE
Absorption of a photon by rhodopsin (MIM.180380) triggers visual signaling in rod photoreceptors.
The phototransduction cascade leads to rapid hydrolysis of cGMP by activated cGMP phosphodiesterase (PDEs), resulting in closure of cGMP-gated cation channels in the plasma membrane and hyperpolarization of the cell.
Rod PDE is a peripheral membrane heterotrimeric enzyme made up of alpha (PDE6A) (MIM.180071), beta (PDE6B), and gamma subunits (PDE6G) (MIM.180073) .