interdigitating dendritic cell sarcoma

Interdigitating dendritic cell sarcoma is an extremely rare neoplasm that mainly occurs in the lymph nodes.

Localization

 lymph nodes: nodal IDCS
 spleen (rare): splenic IDCS (11914634)
 testis (rare): testicular IDCS (10478677)

Microscopical synpopsis

 diffuse proliferation of large pleomorphic cells
 erythrophagocytosis

Immunohistochemistry

 S-100+
 fascin+
 vimentin+
 CD68+

 CD45-
 CD20-
 CD3-
 CD1a-
 CD30-
 complement receptors-
 CD34-
 Factor VIII-
 HMB-45-
 lysozyme-

Cytogenetics

 BCL2 chromosomal translocation is not a general feature of the interdigitating dendritic cell sarcoma. (20736747)

Ultrastructurally

 complex interdigitating cytoplasmic dendritic processes
 Birbeck granules absent

References

 BCL2 chromosomal translocation is not a general feature of the interdigitating dendritic cell sarcoma. Wang HY, Li S, Woodford RL, Mills SE, Cousar JB. Diagn Mol Pathol. 2010 Sep;19(3):169-71. PMID: 20736747

 Pillay K, Solomon R, Daubenton JD, Sinclair-Smith CC. Interdigitating dendritic cell sarcoma: a report of four paediatric cases and review of the literature. Histopathology. 2004 Mar;44(3):283-91. PMID: 14987233

 Kawachi K, Nakatani Y, Inayama Y, Kawano N, Toda N, Misugi K. Interdigitating dendritic cell sarcoma of the spleen: report of a case with a review of the literature. Am J Surg Pathol. 2002 Apr;26(4):530-7. Review. PMID: 11914634

 Gaertner EM, Tsokos M, Derringer GA, Neuhauser TS, Arciero C, Andriko JA. Interdigitating dendritic cell sarcoma. A report of four cases and review of the literature. Am J Clin Pathol. 2001 Apr;115(4):589-97. Review. PMID: 11293908