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DUOXs

The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells.

Contained within this complex is an iodide transporter (MIM.605646), thyroperoxidase (TPO) (MIM.274500), and a peroxide-generating system that includes DUOX1 (MIM.606758) and DUOX2 (MIM.606759).

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DUOX1 DUOX2