USP25
MIM.604736 Chr.21
Function
Ubiquitin (MIM.191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response.
Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25.
Pathology
USP25/RUNX1 fusion gene in leukemias
See also
USPs
References
Groet, J.; Ives, J. H.; Jones, T. A.; Danton, M.; Flomen, R. H.; Sheer, D.; Hrascan, R.; Pavelic, K.; Nizetic, D. : Narrowing of the region of allelic loss in 21q11-21 in squamous non-small cell lung carcinoma and cloning of a novel ubiquitin-specific protease gene from the deleted segment. Genes Chromosomes Cancer 27: 153-161, 2000. PubMed ID : #10612803#