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Tuesday 1 November 2016



- BCOR-ZC3H7B gene fusion in high-grade endometrial stromal sarcoma (27631520)

  • Endometrial stromal sarcomas (ESS) are often underpinned by recurrent chromosomal translocations resulting in the fusion of genes involved in epigenetic regulation.
  • YWHAE-NUTM2 rearrangements also associated with distinctive high-grade ESS and aggressive clinical behavior.
  • ESS with ZC3H7B-BCOR fusion constitutes a novel type of high-grade ESS and shares significant morphologic overlap with myxoid leiomyosarcoma.