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ACADM

MIM.607008 1p31

ACADM codes for MCAD or MCADH, as medium-chain acyl-CoA dehydrogenase.

ACADs

5 acyl-CoA dehydrogenases (ACADs) had been reported:

- short-chain acyl-CoA dehydrogenase (MIM.606885)
- medium-chain acyl-CoA dehydrogenase (EC 1.3.99.3)
- long-chain (609576) acyl-CoA dehydrogenase;
- isovaleryl-CoA dehydrogenase (MIM.243500);
- 2-methyl branched-chain acyl-CoA dehydrogenase.

The first 3 catalyze the initial reaction in the beta-oxidation of fatty acids, while the last 2 catalyze the dehydrogenation of branched short-chain acyl-CoAs in the metabolism of the branched-chain amino acids. All 5 may have evolved from a common ancestral gene.