ARHGDIs
ARHGDIs (RhoGDIs) interact with the GDP-bound Rho proteins (RHOs) to keep them in a resting complex. The GDP-dissociation inhibitors (GDIs) play a primary role in modulating the activation of GTPases by inhibiting the exchange of GDP for GTP.
RHOs, or Aplysia Ras-related homologs (ARHs), belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors. The ARH proteins (RHOs) may be kept in the inactive, GDP-bound state by interaction with GDP dissociation inhibitors (ARHGDIs).
Members of the Rho (RHOs or ARHs) protein family and other Ras-related small GTP-binding proteins are involved in diverse cellular events, including cell signaling, proliferation, cytoskeletal organization, and secretion. The GTP-binding proteins are active only in the GTP-bound state.
At least 3 classes of proteins tightly regulate cycling between the GTP-bound and GDP-bound states:
GTPase-activating proteins (GAPs);
guanine nucleotide-releasing factors (GRFs)
GDP-dissociation inhibitors (ARHGDIs).
The ARHGDIs decrease the rate of GDP dissociation from Ras-like GTPases.
Members
| ARHGDIA | ARHGDIB | ARHGDIC |