The alcohol dehydrogenase (ADH) family of enzymes catalyzes the reversible oxidation of alcohol to acetaldehyde. Seven ADH genes exist in a segment of 370 kb on 4q21.
Products of the three class I ADH genes that share 95% sequence identity are believed to play the major role in the first step of ethanol metabolism.
Members
| ADH1 | ADH2 | ADH3 | ADH4 | ADH5 | ADH6 | ADH7 | ADH8 |
References
Han Y, Gu S, Oota H, Osier MV, Pakstis AJ, Speed WC, Kidd JR, Kidd KK. Evidence of positive selection on a class I ADH locus. Am J Hum Genet. 2007 Mar;80(3):441-56. PMID: 17273965
