esophageal adenocarcinoma

Previously regarded as a rare neoplasm, the incidence of esophageal adenocarcinoma has risen rapidly in recent decades. It is often discovered late in the disease process and has a dismal prognosis.

Oesophageal and gastro-oesophgeal junction (GOJ) adenocarcinoma is increasing in incidence and has a poor outcome.

Images

 peritumoral and intra-tumoral budding in esophageal adenocarcinoma

• https://twitter.com/PathologyTweet/status/741254994901532672

Prognostic factors

 tumor budding is associated with an increased risk of lymph node metastasis and poor prognosis in superficial esophageal adenocarcinoma. (24762549)

Biomarkers

 SMAD4 - MADH4

• Loss of Smad4 protein expression is an independent prognostic factor for TTR and OS that correlates with increased propensity for disease recurrence and poor survival in patients with esophageal adenocarcinoma after surgical resection. (25634752)

Comparative genomic hybridization (16479570)

 losses

• Chr.3 loss
• 4p loss
• 4q loss (18820669)
• 5q loss (18820669)
• Chr.6 loss
• 8p loss
• 9p loss
• 15q loss (18820669)
• 17p loss
• 18q loss (18820669)
• Chr.20 loss

 gains

• 1q gain
• 6p gain (18820669)
• 7p gain
• 7q22.1 gain
• 8q gain (18820669)
• 11q gain
• 13q gain (18820669)
• 15q gain
• 17q gain (18820669)
• 20p gain
• 20q gain (18820669)

Early adenocarcinoma of the esophagus (T1 stage)

Early (T1 stage) adenocarcinoma of the esophagus or gastroesophageal junction is a potentially curable disease.

See also

 esophageal carcinomas

Open references

 Tumor budding is associated with an increased risk of lymph node metastasis and poor prognosis in superficial esophageal adenocarcinoma. Landau MS, Hastings SM, Foxwell TJ, Luketich JD, Nason KS, Davison JM. Mod Pathol. 2014 Dec;27(12):1578-89. doi : 10.1038/modpathol.2014.66 PMID: 24762549 (Free)

References

 Smad4 Loss in Esophageal Adenocarcinoma Is Associated With an Increased Propensity for Disease Recurrence and Poor Survival. Singhi AD, Foxwell TJ, Nason K, Cressman KL, McGrath KM, Sun W, Bahary N, Zeh HJ, Levy RM, Luketich JD, Davison JM. Am J Surg Pathol. 2015 Jan 28. PMID: 25634752

 Pasello G, Agata S, Bonaldi L, Corradin A, Montagna M, Zamarchi R, Parenti A, Cagol M, Zaninotto G, Ruol A, Ancona E, Amadori A, Saggioro D. DNA copy number alterations correlate with survival of esophageal adenocarcinoma patients. Mod Pathol. 2008 Sep 26. PMID: 18820669

 van Dekken H, Wink JC, Vissers KJ, van Marion R, Koppert LB, Tilanus HW, Siersema PD, Tanke HJ, Szuhai K, Hop WC. Genomic analysis of early adenocarcinoma of the esophagus or gastroesophageal junction: tumor progression is associated with alteration of 1q and 8p sequences. Genes Chromosomes Cancer. 2006 May;45(5):516-25. PMID: 16479570

 Lin L, Wang Z, Prescott MS, van Dekken H, Thomas DG, Giordano TJ, Chang AC, Orringer MB, Gruber SB, Moran JV, Glover TW, Beer DG. Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3-q27 are associated with development of esophageal adenocarcinoma. Genes Chromosomes Cancer. 2006 Apr;45(4):319-31. PMID: 16320248