tumor-specific alternative splicing

Alternative splicing is the differential processing of exon junctions to produce a new transcript variant from one gene. Some aberrant splicing, however, has been shown to be cancer specific.

Identification of these specific splice variations provide important insight into the molecular mechanism of normal cellular physiology as well as the disease processes.

Presentation

 "RNA expression and splicing profiling from fine-needle samples" by Dr Philippe Viehl, IGR, France at the 2012 Biopathology Symposium.

See also

 alternative splicing
 alternative splicing isoforms
 carcinogenesis
 tumorigenesis
 differential splicing profile

References

 Guimaraes GS, Latini FR, Camacho CP, Maciel RM, Dias-Neto E, Cerutti JM. Identification of candidates for tumor-specific alternative splicing in the thyroid. Genes Chromosomes Cancer. 2006 Jun;45(6):540-53. PMID: 16493598