MLL10
MIM.602409 10p12
Pathology
PICALM/AF10 fusion gene by t(10;11)(p13;q14) in acute leukemia
- acute lymphoblastic leukaemia (ALL) (#10554802#)
- acute myeloid leukaemia (AML) (#10554802#)
References
Debernardi, S.; Bassini, A.; Jones, L. K.; Chaplin, T.; Linder, B.; de Bruijn, D. R. H.; Meese, E.; Young, B. D. : The MLL fusion partner AF10 binds GAS41, a protein that interacts with the human SWI/SNF complex. Blood 99: 275-281, 2002. PubMed ID : #11756182#
Bohlander, S. K.; Muschinsky, V.; Schrader, K.; Siebert, R.; Schlegelberger, B.; Harder, L.; Schemmel, V.; Fonatsch, C.; Ludwig, W.-D.; Hiddemann, W.; Dreyling, M. H. : Molecular analysis of the CALM/AF10 fusion: identical rearrangements in acute myeloid leukemia, acute lymphoblastic leukemia and malignant lymphoma patients. Leukemia 14: 93-99, 2000. PubMed ID : #10637482#
Carlson, K. M.; Vignon, C.; Bohlander, S.; Martinez-Climent, J. A.; Le Beau, M. M.; Rowley, J. D. : Identification and molecular characterization of CALM/AF10 fusion products in T cell acute lymphoblastic leukemia and acute myeloid leukemia. Leukemia 14: 100-104, 2000. PubMed ID : #10637483#
Dreyling, M. H.; Martinez-Climent, J. A.; Zheng, M.; Mao, J.; Rowley, J. D.; Bohlander, S. K. : The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, a new member of the AP-3 clathrin assembly protein family. Proc. Nat. Acad. Sci. 93: 4804-4809, 1996. PubMed ID : #8643484#
Dreyling, M. H.; Schrader, K.; Fonatsch, C.; Schlegelberger, B.; Haase, D.; Schoch, C.; Ludwig, W.-D.; Loffler, H.; Buchner, T.; Wormann, B.; Hiddemann, W.; Bohlander, S. K. : MLL and CALM are fused to AF10 in morphologically distinct subsets of acute leukemia with translocation t(10;11): both rearrangements are associated with a poor prognosis. Blood 91: 4662-4667, 1998. PubMed ID : #9616163#
Tanabe, S.; Bohlander, S. K.; Vignon, C. V.; Espinosa, R., III; Zhao, N.; Strissel, P. L.; Zeleznik-Le, N. J.; Rowley, J. D. : AF10 is split by MLL and HEAB, a human homolog to a putative Caenorhabditis elegans ATP/GTP-binding protein in an invins(10;11)(p12;q23q12). Blood 88: 3535-3545, 1996. PubMed ID : #8896421#
Chaplin, T.; Ayton, P.; Bernard, O. A.; Saha, V.; Della Valle, V.; Hillion, J.; Gregorini, A.; Lillington, D.; Berger, R.; Young, B. D. : A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia. Blood 85: 1435-1441, 1995. PubMed ID : #7888665#