IRX2
MIM.606198 5p15.3
IRX2 is a member of the Iroquois homeobox gene family IRXs. Members of IRXs family appear to play multiple roles during pattern formation of vertebrate embryos.
Pathology
Copy number gains and high-level amplifications of the short arm of chromosome 5 are frequently observed in soft tissue sarcomas.
amplified and overexpressed in MPNST (#16752383#)
See also
TRIO
NKD2 (overexpressed in MPNSTs)
References
Adamowicz M, Radlwimmer B, Rieker RJ, Mertens D, Schwarzbach M, Schraml P, Benner A, Lichter P, Mechtersheimer G, Joos S. Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas. Genes Chromosomes Cancer. 2006 PMID: #16752383#