Home > A. Molecular pathology > MYB
MYB
MIM.189990 6q22
Monday 3 September 2007
V-MYB AVIAN MYELOBLASTOSIS VIRAL ONCOGENE HOMOLOG
Pathology
MYB overexpression in colorectal cancer (CRC) is a prognostic indicator for poor survival.
MYB duplication by dup(6)(q22-q23) in acute lymphoblastic leukemia (ALL)
MYB-GATA1 fusion gene in acute basophilic leukemia (21474671)
MYB-NFIB fusion gene in cystic carcinoma (ACC)
- mammary adenoid cystic carcinoma (MACC)
- salivary adenoid cystic carcinoma (MACC)
Open References
Identification of a transforming MYB-GATA1 fusion gene in acute basophilic leukemia: a new entity in male infants. Quelen C, Lippert E, Struski S, Demur C, Soler G, Prade N, Delabesse E, Broccardo C, Dastugue N, Mahon FX, Brousset P. Blood. 2011 May 26;117(21):5719-22. PMID: 21474671
References
Hugo H, Cures A, Suraweera N, Drabsch Y, Purcell D, Mantamadiotis T, Phillips W, Dobrovic A, Zupi G, Gonda TJ, Iacopetta B, Ramsay RG. Mutations in the MYB intron I regulatory sequence increase transcription in colon cancers. Genes Chromosomes Cancer. 2006 Dec;45(12):1143-54. PMID: 16977606
