MDR
The multidrug resistant (MDR) phenotype is often attributed to the activity of ATP-binding cassette (ABC) transporters such as P-glycoprotein (ABCB1).
Modulation of MDR may not necessarily be a single gene trait. Integrative analysis suggests that multiple genes are activated during escalation of drug resistance, including a succession of ABC transporter genes and genes that may act synergistically with ABCB1. The MDR phenotype is a dynamic, multi-genic process in the genome of cancer cells.
See also
P-glycoproteins
References
Buys TP, Chari R, Lee EH, Zhang M, Macaulay C, Lam S, Lam WL, Ling V. Genetic changes in the evolution of multidrug resistance for cultured human ovarian cancer cells. Genes Chromosomes Cancer. 2007 Aug 28; PMID: #17726699#