IL12A
MIM.161560 3p12-q13.2
Interleukin-12 (IL-12) has a broad array of potent biologic activities, acting at picomolar and subpicomolar levels on both T and NK cells.
IL12 is a disulfide-linked heterodimer composed of unrelated IL12B (40-kD or p40) (MIM.161561) and 35-kD (p35) subunits.
Pathology
IL-12 is considered a critical proinflammatory cytokine for autoimmune diseases such as multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE).
See also
IL12s: IL12A and IL12B
IL12Rs: IL12RAs and IL12RBs